![]() ![]() After a median follow-up of 34.3 months, the estimated PFS was 77% in all patients and 91% in those who proceeded to ASCT. Subsequently, 67 patients underwent ASCT. The combination of BV and nivolumab led to an objective response rate of 85%, including a complete response rate of 67%. Immune-related adverse events occurred in 16 patients, none of whom discontinued treatment.ĭata analysis included 91 patients who received treatment. At the end of BV-nivolumab treatment, patients could proceed to ASCT at investigator discretion. Both staggered dosing and same-day dosing of BV and nivolumab were evaluated during the trial. ![]() The protocol excluded patients who had received prior salvage therapy. Investigators conducted a multicenter, single-arm phase I/II trial involving adults with biopsy proven r/r cHL. BV and nivolumab are generally well tolerated, providing a rationale to evaluate the combination in r/r cHL. Nivolumab also showed promise as treatment for r/r cHL, leading to an objective response rate of 73% and complete responses in 28%. BV also showed promise as salvage therapy when administered sequentially or in combination with chemotherapy, the authors continued. The antibody-drug conjugate brentuximab vedotin demonstrated single-agent activity in r/r cHL. "Optimal sequencing of the brentuximab-nivolumab regimen with standard salvage chemotherapy and other immunotherapies and the evolving role for stem-cell transplant (SCT) as a function of highly active second-line salvage regimens remain important questions for future studies," stated Yun Choi, MD, and Catherine Diefenbach, MD, both of Perlmutter Cancer Center at NYU Langone Health in New York City. The authors of an accompanying editorial agreed that "this regimen has the potential to provide an alternative to cytotoxic chemotherapy regimens such as ifosfamide, carboplatin, and etoposide as a first salvage therapy, if the findings are confirmed in a randomized trial." "These data continue to support the promise of combining BV and nivolumab as a salvage regimen that is highly active and well tolerated and may potentially offer an alternative to chemotherapy-based salvage in patients with r/r cHL." You Too Can Own an NFA Weapon! Here's how."BV (brentuximab vedotin) and nivolumab as initial salvage therapy, together with ASCT, was well tolerated and provided durable remissions in a high proportion of patients with relapsed/refractory classical Hodgkin lymphoma (r/r cHL)," the authors concluded. Got more questions? The ATF maintains its own FAQ! Ĭome read about the History of the NFA as told by the Bureau of Alcohol, Tobacco, Firearms, and Explosives (ATF). What is the National Firearms Act? Read the text of the law here. Want to see NFA stuff in action? Check out NFA Review Channel! Want to learn about the NFA? Visit our Wiki! u/NauticalMile's guide on suppressor alignment on a budget u/Semper1371's Post-41F ATF eForms Form 1 Guide How to Clip Baffles on a Form 1 Suppressor, by /u/Jojoweiner Rules are subject to change at the discretion of the moderation staff. Moderators have total discretion and all decisions are final. Wish), or any other activity that jeopardize the existence of the subreddit. This also includes, but is not limited to, posting how-to instructions for illegal machinegun conversions, illegal suppressors or DIY-kits (i.e. No posting any material that contains ANY personal information. This includes drug use, unregistered NFA possession, etc. No illegal activity or anything that can be reasonably inferred as involving illegal activity. Posting of firearm 3D print files is not permitted (this is against Reddit TOS) and result in permanent ban, no exceptions. FFL's with proof may post a deal/sale after contacting a mod first. Memes are allowed but MUST be NFA related, all political memes will be removed. Posts related to approval of NFA items are to be directed to the monthly megathread. No political posts, apps that list days waited for NFA items, shitposting, trolling, or duplicate posts. ![]() Racial, harassment, homophobic, sexist posts/comments will result in a permanent ban. When will my transfer be approved? Find out how here.īe kind to fellow users, this process is complicated and not everyone is an expert. What are the Benefits of filing as a Trust vs. Moving With a Pending Form 1 or Form 4 (In State & Out of State)? Here's what to do. How to fill out a standard FD-258 fingerprint ID card as required for any NFA purchase or transfer. What is a Form 5320.23 Responsible Person's Questionnaire and why is it necessary? Now you can have the same proven mounting technology of the KeyMo System found in Dead Airs Sandman Series of silencers on silencers like the Dead Air Ghost, Wolf, and Wolfman. How to fill out a Form 5320.20 to transport some NFA items across state lines. What is a Form 5 and how do I fill one out? Form generators to include forms 1, 4, 5, caliber changes, registry removal, and many more to coincide with NGT’s form guides. ![]()
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